Pathomechanisms Underlying X‐Adrenoleukodystrophy: A Three‐Hit Hypothesis

X‐adrenoleukodystrophy (X‐ALD) is a complex disease where inactivation of ABCD1 gene results in clinically diverse phenotypes, the fatal disorder of cerebral ALD (cALD) or a milder disorder of adrenomyeloneuropathy (AMN). Loss of ABCD1 function results in defective beta oxidation of very long chain...

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Bibliographic Details
Main Authors: Singh, Inderjit, Pujol, Aurora
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2010
Subjects:
MINI‐SYMPOSIUM: X‐Linked Adrenoleukodystrophy
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021280/
https://ncbi.nlm.nih.gov/pubmed/20626745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1750-3639.2010.00392.x
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