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Increasing batch-to-batch reproducibility of CHO cultures by robust open-loop control

In order to guarantee the quality of recombinant therapeutic proteins produced in mammalian cell systems, the straightforward approach in industry is to run the processes as reproducible as possible. It is first shown that considerable distortions in the currently operated processes appear when the...

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Detalles Bibliográficos
Main Authors: Aehle, M., Kuprijanov, A., Schaepe, S., Simutis, R., Lübbert, A.
Formato: Artigo
Idioma:Inglês
Publicado: Springer Netherlands 2010
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021148/
https://ncbi.nlm.nih.gov/pubmed/21057872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10616-010-9320-y
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