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Increasing batch-to-batch reproducibility of CHO cultures by robust open-loop control
In order to guarantee the quality of recombinant therapeutic proteins produced in mammalian cell systems, the straightforward approach in industry is to run the processes as reproducible as possible. It is first shown that considerable distortions in the currently operated processes appear when the...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Springer Netherlands
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3021148/ https://ncbi.nlm.nih.gov/pubmed/21057872 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10616-010-9320-y |
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