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Development of an oncolytic Herpes Simplex Virus using a tumor-specific HIF-responsive promoter
We exploited the differential activation of hypoxia-inducible factor (HIF)-dependent gene expression in tumors versus normal tissue for the design of a targeted oncolytic Herpes simplex virus type-1 (HSV-1). A gene that is essential for viral replication, ICP4, was placed under the regulation of a H...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3021095/ https://ncbi.nlm.nih.gov/pubmed/20930860 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2010.62 |
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