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Nonspecific binding limits the number of proteins in a cell and shapes their interaction networks
Multicellular organisms, from Caenorhabditis elegans to humans, have roughly the same number of protein encoding genes. We show that the need to prevent disease-causing nonspecific interactions between proteins provides a simple physical reason why organism complexity is not reflected in the number...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3021073/ https://ncbi.nlm.nih.gov/pubmed/21187424 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1010954108 |
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