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miR-29 and miR-30 regulate B-Myb expression during cellular senescence

Cellular senescence is a form of irreversible growth arrest and a major tumor suppressor mechanism. We show here that the miR-29 and miR-30 microRNA families are up-regulated during induced and replicative senescence and that up-regulation requires activation of the Rb pathway. Expression of a repor...

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Main Authors: Martinez, Ivan, Cazalla, Demian, Almstead, Laura L., Steitz, Joan A., DiMaio, Daniel
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021067/
https://ncbi.nlm.nih.gov/pubmed/21187425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1017346108
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