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A single-molecule characterization of p53 search on DNA
The tumor suppressor p53 slides along DNA while searching for its cognate site. Central to this process is the basic C-terminal domain, whose regulatory role and its coordination with the core DNA-binding domain is highly debated. Here we use single-molecule techniques to characterize the search pro...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3021058/ https://ncbi.nlm.nih.gov/pubmed/21178072 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1016020107 |
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