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Identification of a gain-of-function mutation in a Golgi P-type ATPase that enhances Mn(2+) efflux and protects against toxicity
P-type ATPases transport a wide array of ions, regulate diverse cellular processes, and are implicated in a number of human diseases. However, mechanisms that increase ion transport by these ubiquitous proteins are not known. SPCA1 is a P-type pump that transports Mn(2+) from the cytosol into the Go...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3021037/ https://ncbi.nlm.nih.gov/pubmed/21187401 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1013642108 |
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