Critical role of aquaporin-4 (AQP4) in astrocytic Ca(2+) signaling events elicited by cerebral edema

Aquaporin-4 (AQP4) is a primary influx route for water during brain edema formation. Here, we provide evidence that brain swelling triggers Ca(2+) signaling in astrocytes and that deletion of the Aqp4 gene markedly interferes with these events. Using in vivo two-photon imaging, we show that hypoosmo...

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Autors principals: Thrane, Alexander S., Rappold, Phillip M., Fujita, Takumi, Torres, Arnulfo, Bekar, Lane K., Takano, Takahiro, Peng, Weiguo, Wang, Fushun, Thrane, Vinita Rangroo, Enger, Rune, Haj-Yasein, Nadia N., Skare, Øivind, Holen, Torgeir, Klungland, Arne, Ottersen, Ole P., Nedergaard, Maiken, Nagelhus, Erlend A.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2011
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021020/
https://ncbi.nlm.nih.gov/pubmed/21187412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015217108
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