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Creatine Transporter (CrT; Slc6a8) Knockout Mice as a Model of Human CrT Deficiency

Mutations in the creatine (Cr) transporter (CrT; Slc6a8) gene lead to absence of brain Cr and intellectual disabilities, loss of speech, and behavioral abnormalities. To date, no mouse model of CrT deficiency exists in which to understand and develop treatments for this condition. The purpose of thi...

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Main Authors: Skelton, Matthew R., Schaefer, Tori L., Graham, Devon L., deGrauw, Ton J., Clark, Joseph F., Williams, Michael T., Vorhees, Charles V.
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2011
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גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020968/
https://ncbi.nlm.nih.gov/pubmed/21249153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016187
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