Large Proteins Have a Great Tendency to Aggregate but a Low Propensity to Form Amyloid Fibrils

The assembly of soluble proteins into ordered fibrillar aggregates with cross-β structure is an essential event of many human diseases. The polypeptides undergoing aggregation are generally small in size. To explore if the small size is a primary determinant for the formation of amyloids under patho...

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Main Authors: Ramshini, Hassan, Parrini, Claudia, Relini, Annalisa, Zampagni, Mariagioia, Mannini, Benedetta, Pesce, Alessandra, Saboury, Ali Akbar, Nemat-Gorgani, Mohsen, Chiti, Fabrizio
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020945/
https://ncbi.nlm.nih.gov/pubmed/21249193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016075
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