Ligation of Prostate Cancer Cell Surface GRP78 Activates a Proproliferative and Antiapoptotic Feedback Loop: A ROLE FOR SECRETED PROSTATE-SPECIFIC ANTIGEN

GRP78, a well characterized chaperone in the endoplasmic reticulum, is critical to the unfolded protein response. More recently, it has been identified on the cell surface, where it has many roles. On cancer cells, it functions as a signaling receptor coupled to proproliferative/antiapoptotic and pr...

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Bibliografiske detaljer
Main Authors: Misra, Uma K., Payne, Sturgis, Pizzo, Salvatore V.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020732/
https://ncbi.nlm.nih.gov/pubmed/21056970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.129767
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