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Evidence for a Pro-Proliferative Feedback Loop in Prostate Cancer: The Role of Epac1 and COX-2-Dependent Pathways

OBJECTIVE: In human prostate cancer cells, a selective Epac agonist, 8-CPT-2Me-cAMP, upregulates cell proliferation and survival via activation of Ras-MAPK and PI- 3-kinase-Akt-mTOR signaling cascades. Here we examine the role of inflammatory mediators in Epac1-induced cellular proliferation by dete...

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Bibliografiske detaljer
Main Authors: Misra, Uma Kant, Pizzo, Salvatore Vincent
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640024/
https://ncbi.nlm.nih.gov/pubmed/23646189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0063150
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