Calcineurin/Nuclear Factor of Activated T Cells and MAPK Signaling Induce TNF-α Gene Expression in Pancreatic Islet Endocrine Cells

Cytokines contribute to pancreatic islet inflammation, leading to impaired glucose homeostasis and diabetic diseases. A plethora of data shows that proinflammatory cytokines are produced in pancreatic islets by infiltrating mononuclear immune cells. Here, we show that pancreatic islet α cells and β...

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Detalhes bibliográficos
Principais autores: Lawrence, Michael C., Naziruddin, Bashoo, Levy, Marlon F., Jackson, Andrew, McGlynn, Kathleen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020709/
https://ncbi.nlm.nih.gov/pubmed/21059644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.158675
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