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Mechanism of regulation of the hypoxia-inducible factor-1α by the von Hippel-Lindau tumor suppressor protein
In normoxic cells the hypoxia-inducible factor-1α (HIF-1α) is rapidly degraded by the ubiquitin-proteasome pathway, and activation of HIF-1α to a functional form requires protein stabilization. Here we show that the product of the von Hippel-Lindau (VHL) tumor suppressor gene mediated ubiquitylation...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Oxford University Press
2000
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC302039/ https://ncbi.nlm.nih.gov/pubmed/10944113 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.16.4298 |
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