Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice

To determine whether insulin action on endothelial cells promotes or protects against atherosclerosis, we generated apolipoprotein E null mice in which the insulin receptor gene was intact or conditionally deleted in vascular endothelial cells. Insulin sensitivity, glucose tolerance, plasma lipids,...

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Detalhes bibliográficos
Main Authors: Rask-Madsen, Christian, Li, Qian, Freund, Bryn, Feather, Danielle, Abramov, Roman, Wu, I-Hsien, Chen, Kai, Yamamoto-Hiraoka, Junko, Goldenbogen, Jan, Sotiropoulos, Konstantinos B., Clermont, Allen, Geraldes, Pedro, Dall'Osso, Claudia, Wagers, Amy J., Huang, Paul L., Rekhter, Mark, Scalia, Rosario, Kahn, C. Ronald, King, George L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020149/
https://ncbi.nlm.nih.gov/pubmed/20444418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2010.03.013
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