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The equine herpesvirus-1 (EHV-1) IR3 transcript downregulates expression of the IE gene and the absence of IR3 gene expression alters EHV-1 biological properties and virulence

The IR3 transcript of equine herpesvirus-1 (EHV-1) harbors 117 nts antisense to the immediate-early (IE) mRNA, suggesting it plays a regulatory role. Here, we show that the IR3 transcript downregulates IE gene expression and that the absence of IR3 expression altered EHV-1 biological properties and...

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Bibliografiske detaljer
Main Authors: Ahn, Byung Chul, Zhang, Yunfei, O’Callaghan, Dennis J.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020145/
https://ncbi.nlm.nih.gov/pubmed/20417949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2010.03.051
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