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Association of GCN1–GCN20 regulatory complex with the N-terminus of eIF2α kinase GCN2 is required for GCN2 activation
Stimulation of GCN4 mRNA translation due to phosphorylation of the α-subunit of initiation factor 2 (eIF2) by its specific kinase, GCN2, requires binding of uncharged tRNA to a histidyl-tRNA synthetase (HisRS)-like domain in GCN2. GCN2 function in vivo also requires GCN1 and GCN20, but it was unknow...
Enregistré dans:
| Publié dans: | EMBO J |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2000
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC302013/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10775272/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.8.1887 |
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