MyD88 Deficiency Leads to Decreased NK Cell Gamma Interferon Production and T Cell Recruitment during Chlamydia muridarum Genital Tract Infection, but a Predominant Th1 Response and Enhanced Monocytic Inflammation Are Associated with Infection Resolution

We have previously shown that MyD88 knockout (KO) mice exhibit delayed clearance of Chlamydia muridarum genital infection compared to wild-type (WT) mice. A blunted Th1 response and ineffective suppression of the Th2 response were also observed in MyD88 KO mice. The goal of the present study was to...

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Hlavní autoři: Nagarajan, Uma M., Sikes, James, Prantner, Daniel, Andrews, Charles W., Frazer, Lauren, Goodwin, Anna, Snowden, Jessica N., Darville, Toni
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2011
Témata:
Host Response and Inflammation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3019903/
https://ncbi.nlm.nih.gov/pubmed/21078858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00843-10
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