Mutant feedback-resistant phosphoribosylpyrophosphate synthetase associated with purine overproduction and gout. Phosphoribosylpyrophosphate and purine metabolism in cultured fibroblasts.

We have reported previously two siblings with gout and uric acid lithiasis associated with excessive purine production. In the erythrocytes of these patients, phosphoribosylpyrophosphate (PRPP) synthetase exhibited resistance to feedback-inhibition by normal cell constituents such as guanosine-5...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Zoref, E, De Vries, A, Sperling, O
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 1975
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC301970/
https://ncbi.nlm.nih.gov/pubmed/171280
Etiketak: Etiketa erantsi
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