PA-824 Exhibits Time-Dependent Activity in a Murine Model of Tuberculosis

PA-824 is one of two nitroimidazoles in phase II clinical trials to treat tuberculosis. In mice, it has dose-dependent early bactericidal and sterilizing activity. In humans with tuberculosis, PA-824 demonstrated early bactericidal activity (EBA) at doses ranging from 200 to 1,200 mg per day, but no...

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Autors principals: Ahmad, Zahoor, Peloquin, Charles A., Singh, Rajendra P., Derendorf, Hartmut, Tyagi, Sandeep, Ginsberg, Ann, Grosset, Jacques H., Nuermberger, Eric L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2011
Matèries:
Experimental Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3019674/
https://ncbi.nlm.nih.gov/pubmed/20937781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00849-10
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