Structure of the Mycobacterium tuberculosis d-Alanine:d-Alanine Ligase, a Target of the Antituberculosis Drug d-Cycloserine

d-Alanine:d-alanine ligase (EC 6.3.2.4; Ddl) catalyzes the ATP-driven ligation of two d-alanine (d-Ala) molecules to form the d-alanyl:d-alanine dipeptide. This molecule is a key building block in peptidoglycan biosynthesis, making Ddl an attractive target for drug development. d-Cycloserine (DCS),...

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Hlavní autoři: Bruning, John B., Murillo, Ana C., Chacon, Ofelia, Barletta, Raúl G., Sacchettini, James C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2011
Témata:
Mechanisms of Action: Physiological Effects
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3019625/
https://ncbi.nlm.nih.gov/pubmed/20956591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00558-10
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