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Identification of Critical Residues of the Mycobacterial Dephosphocoenzyme A Kinase by Site-Directed Mutagenesis

Dephosphocoenzyme A kinase performs the transfer of the γ-phosphate of ATP to dephosphocoenzyme A, catalyzing the last step of coenzyme A biosynthesis. This enzyme belongs to the P-loop-containing NTP hydrolase superfamily, all members of which posses a three domain topology consisting of a CoA doma...

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Bibliographic Details
Main Authors: Walia, Guneet, Gajendar, Komatireddy, Surolia, Avadhesha
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3019153/
https://ncbi.nlm.nih.gov/pubmed/21264299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015228
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