Dual blocking of mTor and PI3K elicits a prodifferentiation effect on glioblastoma stem-like cells

Glioblastoma, the most intractable cerebral tumor, is highly lethal. Recent studies suggest that cancer stem-like cells (CSLCs) have the capacity to repopulate tumors and mediate radio- and chemoresistance, implying that future therapies may need to turn from the elimination of rapidly dividing, but...

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Detalhes bibliográficos
Main Authors: Sunayama, Jun, Sato, Atsushi, Matsuda, Ken-ichiro, Tachibana, Ken, Suzuki, Kaori, Narita, Yoshitaka, Shibui, Soichiro, Sakurada, Kaori, Kayama, Takamasa, Tomiyama, Arata, Kitanaka, Chifumi
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3018946/
https://ncbi.nlm.nih.gov/pubmed/20861085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noq103
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