Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma

Neuralized (Neurl) is a highly conserved E3 ubiquitin ligase, which in Drosophila acts upon Notch ligands to regulate Notch pathway signaling. Human Neuralized1 (NEURL1) was investigated as a potential tumor suppressor in medulloblastoma (MB). The gene is located at 10q25.1, a region demonstrating f...

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Autors principals: Teider, Natalia, Scott, Deborah K., Neiss, Adrianne, Weeraratne, S. Dilhan, Amani, Vladimir M., Wang, Yifei, Marquez, Victor E., Cho, Yoon-Jae, Pomeroy, Scott L.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2010
Matèries:
Basic and Translational Investigations
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3018940/
https://ncbi.nlm.nih.gov/pubmed/20847082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noq091
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