miR-34a confers chemosensitivity through modulation of MAGE-A and p53 in medulloblastoma

Recent studies have established miR-34a as a key effector of the p53 signaling pathway and have implicated its role in multiple cancer types. Here, we establish that miR-34a induces apoptosis, G2 arrest, and senescence in medulloblastoma and renders these cells more sensitive to chemotherapeutic age...

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Detalhes bibliográficos
Main Authors: Weeraratne, Shyamal D., Amani, Vladimir, Neiss, Adrianne, Teider, Natalia, Scott, Deborah K., Pomeroy, Scott L., Cho, Yoon-Jae
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064629/
https://ncbi.nlm.nih.gov/pubmed/21177782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noq179
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