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Influence of blood-brain barrier efflux pumps on the distribution of vincristine in brain and brain tumors
Vincristine (VCR) is efficacious in some but not all brain cancers and an established substrate of Pgp and Mrp1. However, the extent to which such transporters affect the VCR penetration through the blood-brain barrier (BBB) is poorly understood. To evaluate the role of Pgp and Mrp1 in VCR CNS distr...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3018922/ https://ncbi.nlm.nih.gov/pubmed/20501632 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noq056 |
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