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Trichostatin A reverses skewed expression of CD154, interleukin-10, and interferon-γ gene and protein expression in lupus T cells

In systemic lupus erythematosus (SLE), T helper cells exhibit increased and prolonged expression of cell-surface CD40 ligand (CD154), spontaneously overproduce interleukin-10 (IL-10), but underproduce interferon-gamma (IFN-γ). We tested the hypothesis that the imbalance of these gene products reflec...

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Detalhes bibliográficos
Main Authors: Mishra, Nilamadhab, Brown, Doris R., Olorenshaw, Irene M., Kammer, Gary M.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC30189/
https://ncbi.nlm.nih.gov/pubmed/11226290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.051507098
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