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Effector mechanisms of interleukin-17 in collagen-induced arthritis in the absence of interferon-γ and counteraction by interferon-γ

INTRODUCTION: Interleukin (IL)-17 is a pro-inflammatory cytokine in rheumatoid arthritis (RA) and collagen-induced arthritis (CIA). Since interferon (IFN)-γ inhibits Th17 cell development, IFN-γ receptor knockout (IFN-γR KO) mice develop CIA more readily. We took advantage of this model to analyse t...

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Detalhes bibliográficos
Main Authors: Kelchtermans, Hilde, Schurgers, Evelien, Geboes, Lies, Mitera, Tania, Van Damme, Jo, Van Snick, Jacques, Uyttenhove, Catherine, Matthys, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745806/
https://ncbi.nlm.nih.gov/pubmed/19686583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2787
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