Targeted Inhibition of Interleukin-6 with CNTO 328 Sensitizes Pre-clinical Models of Multiple Myeloma to Dexamethasone-mediated Cell Death

Interleukin (IL)-6-mediated signaling attenuates the anti-myeloma activity of glucocorticoids (GCs). We therefore sought to evaluate whether CNTO 328, an anti-IL-6 monoclonal antibody in clinical development, could enhance the apoptotic activity of dexamethasone (dex) in pre-clinical models of myelo...

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Main Authors: Voorhees, Peter M., Chen, Qing, Small, George W., Kuhn, Deborah J., Hunsucker, Sally A., Nemeth, Jeffrey A., Orlowski, Robert Z.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3018832/
https://ncbi.nlm.nih.gov/pubmed/19344406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2141.2009.07647.x
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