FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages

The macrophage-mediated inflammatory response is a key etiologic component of obesity-related tissue inflammation and insulin resistance. The transcriptional factor FoxO1 is a key regulator of cell metabolism, cell cycle and cell death. Its activity is tightly regulated by the phosphoinositide-3-kin...

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Main Authors: Fan, WuQiang, Morinaga, Hidetaka, Kim, Jane J, Bae, Eunju, Spann, Nathanael J, Heinz, Sven, Glass, Christopher K, Olefsky, Jerrold M
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3018786/
https://ncbi.nlm.nih.gov/pubmed/21045807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.268
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