FOXO1 Transrepresses Peroxisome Proliferator-activated Receptor γ Transactivation, Coordinating an Insulin-induced Feed-forward Response in Adipocytes

The transcriptional factor FoxO1 plays an important role in metabolic homeostasis. Herein we identify a novel transrepressional function that converts FoxO1 from an activator of transcription to a promoter-specific repressor of peroxisome proliferator-activated receptor γ (PPARγ) target genes that r...

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Autores principales: Fan, WuQiang, Imamura, Takeshi, Sonoda, Noriyuki, Sears, Dorothy D., Patsouris, David, Kim, Jane J., Olefsky, Jerrold M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Materias:
Mechanisms of Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673287/
https://ncbi.nlm.nih.gov/pubmed/19246449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808915200
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