The checkpointkinase 2 (CHK2) 1100delC germ line mutation is not associated with the development of squamous cell carcinoma of the head and neck (SCCHN)

BACKGROUND: The checkpointkinase 2 (CHK2) is part of the highly conserved ATM-CHK2 signaling pathway, which is activated in response to DNA damage, in particular after double strand breaks which can be caused by carcinogens like smoking. After induction of downstream targets, e.g. the tumor suppress...

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Detalhes bibliográficos
Main Authors: Scheckenbach, Kathrin, Papadopoulou, Galatia, Hoffmann, Thomas K, Chaker, Adam, Bier, Henning, Schipper, Jörg, Balz, Vera, Wagenmann, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3018459/
https://ncbi.nlm.nih.gov/pubmed/21184685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1477-5751-9-10
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