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Familial breast cancer and the hCHK2 1100delC mutation: assessing cancer risk

Germline mutations in the human checkpoint gene, hCHK2, were first identified in 1999 in cases of Li–Fraumeni syndrome. Recent studies have demonstrated that the hCHK2 1100delC mutation acts as a low-penetrance tumour suppressor gene in familial breast cancer not associated with mutations in BRCA1 o...

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Detalhes bibliográficos
Main Authors: Varley, Jenny, Haber, Daniel A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC164998/
https://ncbi.nlm.nih.gov/pubmed/12793891
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