Rac1-mediated signaling plays a central role in secretion-dependent platelet aggregation in human blood stimulated by atherosclerotic plaque

BACKGROUND: Platelet activation requires rapid remodeling of the actin cytoskeleton which is regulated by small GTP-binding proteins. By using the Rac1-specific inhibitor NSC23766, we have recently found that Rac1 is a central component of a signaling pathway that regulates dephosphorylation and act...

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Hlavní autoři: Dwivedi, Suman, Pandey, Dharmendra, Khandoga, Anna L, Brandl, Richard, Siess, Wolfgang
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2010
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3018435/
https://ncbi.nlm.nih.gov/pubmed/21134286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-8-128
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