c-Jun NH(2)-terminal kinase-dependent upregulation of DR5 mediates cooperative induction of apoptosis by perifosine and TRAIL

BACKGROUND: Perifosine, an alkylphospholipid tested in phase II clinical trials, modulates the extrinsic apoptotic pathway and cooperates with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to augment apoptosis. The current study focuses on revealing the mechanisms by which perifosi...

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Bibliografiske detaljer
Main Authors: Fu, Lei, Lin, Yi-Dan, Elrod, Heath A, Yue, Ping, Oh, Youtake, Li, Bo, Tao, Hui, Chen, Georgia Z, Shin, Dong M, Khuri, Fadlo R, Sun, Shi-Yong
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2010
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3018404/
https://ncbi.nlm.nih.gov/pubmed/21172010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-315
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