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Guanine Nucleotide Pool Imbalance Impairs Multiple Steps of Protein Synthesis and Disrupts GCN4 Translational Control in Saccharomyces cerevisiae

Purine nucleotides are structural components of the genetic material, function as phosphate donors, participate in cellular signaling, are cofactors in enzymatic reactions, and constitute the main carriers of cellular energy. Thus, imbalances in A/G nucleotide biosynthesis affect nearly the whole ce...

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Detalhes bibliográficos
Main Authors: Iglesias-Gato, Diego, Martín-Marcos, Pilar, Santos, María A., Hinnebusch, Alan G., Tamame, Mercedes
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3018310/
https://ncbi.nlm.nih.gov/pubmed/20980241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.110.122135
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