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Guanine Nucleotide Pool Imbalance Impairs Multiple Steps of Protein Synthesis and Disrupts GCN4 Translational Control in Saccharomyces cerevisiae

Purine nucleotides are structural components of the genetic material, function as phosphate donors, participate in cellular signaling, are cofactors in enzymatic reactions, and constitute the main carriers of cellular energy. Thus, imbalances in A/G nucleotide biosynthesis affect nearly the whole ce...

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Autori principali: Iglesias-Gato, Diego, Martín-Marcos, Pilar, Santos, María A., Hinnebusch, Alan G., Tamame, Mercedes
Natura: Artigo
Lingua:Inglês
Pubblicazione: Genetics Society of America 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3018310/
https://ncbi.nlm.nih.gov/pubmed/20980241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.110.122135
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