Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action

We present a cross-species chemogenomic screening platform using libraries of haploid deletion mutants from two yeast species, Saccharomyces cerevisiae and Schizosaccharomyces pombe. We screened a set of compounds of known and unknown mode of action (MoA) and derived quantitative drug scores (or D-s...

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Detalhes bibliográficos
Main Authors: Kapitzky, Laura, Beltrao, Pedro, Berens, Theresa J, Gassner, Nadine, Zhou, Chunshui, Wüster, Arthur, Wu, Julie, Babu, M Madan, Elledge, Stephen J, Toczyski, David, Lokey, R Scott, Krogan, Nevan J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3018166/
https://ncbi.nlm.nih.gov/pubmed/21179023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2010.107
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