Mutations in nsP1 and PE2 are critical determinants of Ross River virus-induced musculoskeletal inflammatory disease in a mouse model

The viral determinants of Alphavirus-induced rheumatic disease have not been elucidated. We identified an RRV strain (DC5692) which, in contrast to the T48 strain, does not induce musculoskeletal inflammation in a mouse model of RRV disease. Substitution of the RRV T48 strain nonstructural protein 1...

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Autores principales: Jupille, Henri J., Oko, Lauren, Stoermer, Kristina A., Heise, Mark T., Mahalingam, Suresh, Gunn, Bronwyn M., Morrison, Thomas E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3017666/
https://ncbi.nlm.nih.gov/pubmed/21131014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2010.11.012
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