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Human single-nucleotide polymorphisms alter p53 sequence-specific binding at gene regulatory elements
p53 coordinates the expression of an intricate network of genes in response to stress signals. Sequence-specific DNA binding is essential for p53-mediated tumor suppression. We evaluated the impact of single-nucleotide polymorphisms (SNPs) in p53 response elements (p53RE) on DNA binding and gene exp...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3017610/ https://ncbi.nlm.nih.gov/pubmed/20817676 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq764 |
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