Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing

A common goal in the discovery of rare functional DNA variants via medical resequencing is to incur a relatively lower proportion of false positive base-calls. We developed a novel statistical method for resequencing arrays (SRMA, sequence robust multi-array analysis) to increase the accuracy of det...

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Bibliografiska uppgifter
Huvudupphovsmän: Wang, Wenyi, Shen, Peidong, Thiyagarajan, Sreedevi, Lin, Shengrong, Palm, Curtis, Horvath, Rita, Klopstock, Thomas, Cutler, David, Pique, Lynn, Schrijver, Iris, Davis, Ronald W., Mindrinos, Michael, Speed, Terence P., Scharfe, Curt
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2011
Ämnen:
Computational Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3017602/
https://ncbi.nlm.nih.gov/pubmed/20843780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq750
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