Comprehensive Analysis of MGMT Promoter Methylation: Correlation with MGMT Expression and Clinical Response in GBM

O(6)-methylguanine DNA-methyltransferase (MGMT) promoter methylation has been identified as a potential prognostic marker for glioblastoma patients. The relationship between the exact site of promoter methylation and its effect on gene silencing, and the patient's subsequent response to therapy...

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Bibliographic Details
Main Authors: Shah, Nameeta, Lin, Biaoyang, Sibenaller, Zita, Ryken, Timothy, Lee, Hwahyung, Yoon, Jae-Geun, Rostad, Steven, Foltz, Greg
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3017549/
https://ncbi.nlm.nih.gov/pubmed/21249131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016146
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