Active Adenoviral Vascular Penetration by Targeted Formation of Heterocellular Endothelial–epithelial Syncytia

The endothelium imposes a structural barrier to the extravasation of systemically delivered oncolytic adenovirus (Ad). Here, we introduced a transendothelial route of delivery in order to increase tumor accumulation of virus particles (vp) beyond that resulting from convection-dependent extravasatio...

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Detalhes bibliográficos
Main Authors: Chen, Hannah H, Cawood, Ryan, El-Sherbini, Yasser, Purdie, Laura, Bazan-Peregrino, Miriam, Seymour, Leonard W, Carlisle, Robert C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3017442/
https://ncbi.nlm.nih.gov/pubmed/20877345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.209
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