Defect in insulin binding to receptors in obese man. Amelioration with calorie restriction.
With insulin at 0.1 ng/ml, the binding of (125I)insulin in vitro to circulating lymphocytes from 11 obese patients was less than that observed with cells from 10 thin volunteers. Furthermore, with obese cells, unlabeled insulin was less effective in competing with labeled hormone for binding, both a...
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| Udgivet i: | J Clin Invest |
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| Principais autores: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Clinical Investigation
1975
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC301728/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1109176/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI107907 |
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