Structural Basis for the Recognition of Cellular mRNA Export Factor REF by Herpes Viral Proteins HSV-1 ICP27 and HVS ORF57

The herpesvirus proteins HSV-1 ICP27 and HVS ORF57 promote viral mRNA export by utilizing the cellular mRNA export machinery. This function is triggered by binding to proteins of the transcription-export (TREX) complex, in particular to REF/Aly which directs viral mRNA to the TAP/NFX1 pathway and, s...

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Detalhes bibliográficos
Main Authors: Tunnicliffe, Richard B., Hautbergue, Guillaume M., Kalra, Priti, Jackson, Brian R., Whitehouse, Adrian, Wilson, Stuart A., Golovanov, Alexander P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3017119/
https://ncbi.nlm.nih.gov/pubmed/21253573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1001244
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