Directed evolution and targeted mutagenesis to murinize listeria monocytogenes internalin A for enhanced infectivity in the murine oral infection model

BACKGROUND: Internalin A (InlA) is a critical virulence factor which mediates the initiation of Listeria monocytogenes infection by the oral route in permissive hosts. The interaction of InlA with the host cell ligand E-cadherin efficiently stimulates L. monocytogenes entry into human enterocytes, b...

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Hauptverfasser: Monk, Ian R, Casey, Pat G, Hill, Colin, Gahan, Cormac GM
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2010
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3016325/
https://ncbi.nlm.nih.gov/pubmed/21144051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2180-10-318
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