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Conjugates of Betulin Derivatives with AZT as Potent Anti-HIV Agents

Fourteen novel conjugates of 3,28-di-O-acylbetulins with AZT were prepared as anti-HIV agents, based on our previously reported potent anti-HIV triterpene leads, including 3-O-acyl and 3,28-di-O-acylbetulins. Nine of the conjugates (49–53, 55, 56, 59, 60) exhibited potent anti-HIV activity at the su...

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Detalhes bibliográficos
Main Authors: Xiong, Juan, Kashiwada, Yoshiki, Chen, Chin-Ho, Qian, Keduo, Morris-Natschke, Susan L., Lee, Kuo-Hsiung, Takaishi, Yoshihisa
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3016297/
https://ncbi.nlm.nih.gov/pubmed/20673723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.06.092
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