Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures

BACKGROUND: Hedgehog (HH) signaling is critical for the expansion of granule neuron precursors (GNPs) within the external granular layer (EGL) during cerebellar development. Aberrant HH signaling within GNPs is thought to give rise to medulloblastoma (MB) - the most commonly-observed form of maligna...

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Bibliografske podrobnosti
Main Authors: Cohen, Joseph R, Resnick, Daniel Z, Niewiadomski, Pawel, Dong, Hongmei, Liau, Linda M, Waschek, James A
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3016295/
https://ncbi.nlm.nih.gov/pubmed/21143927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-676
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