Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures

BACKGROUND: Hedgehog (HH) signaling is critical for the expansion of granule neuron precursors (GNPs) within the external granular layer (EGL) during cerebellar development. Aberrant HH signaling within GNPs is thought to give rise to medulloblastoma (MB) - the most commonly-observed form of maligna...

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Detalhes bibliográficos
Main Authors: Cohen, Joseph R, Resnick, Daniel Z, Niewiadomski, Pawel, Dong, Hongmei, Liau, Linda M, Waschek, James A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3016295/
https://ncbi.nlm.nih.gov/pubmed/21143927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-676
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