Effects of a defective ERAD pathway on growth and heterologous protein production in Aspergillus niger

Endoplasmic reticulum associated degradation (ERAD) is a conserved mechanism to remove misfolded proteins from the ER by targeting them to the proteasome for degradation. To assess the role of ERAD in filamentous fungi, we have examined the consequences of disrupting putative ERAD components in the...

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Main Authors: Carvalho, Neuza D. S. P., Arentshorst, Mark, Kooistra, Rolf, Stam, Hein, Sagt, Cees M., van den Hondel, Cees A. M. J. J., Ram, Arthur F. J.
Format: Artigo
Jezik:Inglês
Izdano: Springer-Verlag 2010
Teme:
Applied Genetics and Molecular Biotechnology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3016150/
https://ncbi.nlm.nih.gov/pubmed/20922374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00253-010-2916-5
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