Butyrate Greatly Enhances Derivation of Human Induced Pluripotent Stem Cells by Promoting Epigenetic Remodeling and the Expression of Pluripotency-Associated Genes

We report here that butyrate, a naturally occurring fatty acid commonly used as a nutritional supplement and differentiation agent, greatly enhances the efficiency of induced pluripotent stem (iPS) cell derivation from human adult or fetal fibroblasts. After transient butyrate treatment, the iPS cel...

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Hauptverfasser: Mali, Prashant, Chou, Bin-Kuan, Yen, Jonathan, Ye, Zhaohui, Zou, Jizhong, Dowey, Sarah, Brodsky, Robert A., Ohm, Joyce E., Yu, Wayne, Baylin, Stephen B., Yusa, Kosuke, Bradley, Allan, Meyers, David J., Mukherjee, Chandrani, Cole, Philip A., Cheng, Linzhao
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3015217/
https://ncbi.nlm.nih.gov/pubmed/20201064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.402
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